"Free nerve ending terminal morphology is fiber-type-specific for A delta and C fibers innervating rabbit corneal epithelium". "Thermal detection thresholds of Aδ- and C-fibre afferents activated by brief CO2 laser pulses applied onto the human hairy skin". ^ Churyukanov M, Plaghki L, Legrain V, Mouraux A (2012).Evidence for two different heat transduction mechanisms in nociceptive primary afferents innervating monkey skin. ^ Rolf-Detlef Treede, Richard A.Meyer, Srinivasa N.Raja, James N.Campbell.In other words, they express polymodality. Thus, different free nerve endings work as thermoreceptors, cutaneous mechanoreceptors and nociceptors. Modality įree nerve endings can detect temperature, mechanical stimuli (touch, pressure, stretch) or danger ( nociception). A delta type II fibers are fast-adapting while A delta type I and C fibers are slowly adapting. FNEs infiltrate the middle layers of the dermis and surround hair follicles.įree nerve endings have different rates of adaptation, stimulus modalities, and fiber types.ĭifferent types of FNE can be rapidly adapting, intermediate adapting, or slowly adapting. They penetrate the dermis and end in the stratum granulosum. They are the most common type of nerve ending, and are most frequently found in the skin. They function as cutaneous nociceptors and are essentially used by vertebrates to detect noxious stimuli that often result in pain.įree nerve endings are unencapsulated and have no complex sensory structures. Afferent in this case means bringing information from the body's periphery toward the brain. A free nerve ending ( FNE) or bare nerve ending, is an unspecialized, afferent nerve fiber sending its signal to a sensory neuron.
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